生理活性の詳細Selective PPAR-γ agonist (EC50 values are 280, >1000 and >1000 nM for PPAR isoforms γ, α and δ, respectively). Does not readily cross the blood-brain barrier. Antidiabetic activities in vivo, improves the response to circulating insulin.
保存方法Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Heneka MT et al. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain128:1442-53 (2005).
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Xu HE et al. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A98:13919-24 (2001).
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Colca JR et al. Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats. Diabetes40:1669-74 (1991).
Read more (PubMed: 1756906) »