製品の概要

  • 製品名Anti-PINX1 antibody
    PINX1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PINX1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from internal region of Human PINX1.

  • ポジティブ・コントロール
    • Human heart tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
    Note: without Mg2+ and Ca2+
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab111222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
  • 組織特異性Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
  • 配列類似性Belongs to the PINX1 family.
    Contains 1 G-patch domain.
  • ドメインThe TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
    The TBM domain mediates interaction with TERF1.
  • 細胞内局在Nucleus. Nucleus > nucleolus. Chromosome > telomere. Chromosome > centromere > kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 67-11-3 protein antibody
    • FLJ20565 antibody
    • Hepatocellular carcinoma-related putative tumor suppressor antibody
    • Liver-related putative tumor suppressor antibody
    • LPTL antibody
    • LPTS antibody
    • MGC8850 antibody
    • OTTHUMP00000224984 antibody
    • OTTHUMP00000224985 antibody
    • OTTHUMP00000224986 antibody
    • OTTHUMP00000225053 antibody
    • OTTHUMP00000225054 antibody
    • PIN2 interacting protein 1 antibody
    • Pin2-interacting protein X1 antibody
    • PIN2/TERF1-interacting telomerase inhibitor 1 antibody
    • PINX1 antibody
    • PINX1_HUMAN antibody
    • Protein 67-11-3 antibody
    • TRF1-interacting protein 1 antibody
    see all

Anti-PINX1 antibody 画像

  • Immunohistochemistry analysis of paraffin-embedded Human heart tissue, using ab111222 at a dilution of 1/50. Picture at the right with blocking peptide at 10 µg.

Anti-PINX1 antibody (ab111222) 使用論文

ab111222 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab111222.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"