製品の概要

  • 製品名Anti-Pinin antibody
    Pinin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Pinin
  • アプリケーション適用あり: IP, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment (His-tag) corresponding to Pinin aa 1-132.

  • ポジティブ・コントロール
    • U2OS cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab108485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 82 kDa.

ターゲット情報

  • 機能Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
  • 組織特異性Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
  • 配列類似性Belongs to the pinin family.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
    • Desmosome-associated protein antibody
    • Domain-rich serine protein antibody
    • DRS antibody
    • DRS protein antibody
    • DRSP antibody
    • Melanoma metastasis clone A protein antibody
    • MEMA antibody
    • Nuclear protein SDK3 antibody
    • Pinin antibody
    • PININ_HUMAN antibody
    • PNN antibody
    • SR like protein antibody
    • SR-like protein antibody
    see all

Anti-Pinin antibody (ab108485) 使用論文

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"