製品の概要

  • 製品名Anti-PIM1 antibody
    PIM1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to PIM1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Cat
  • 免疫原

    Synthetic peptide:

    C-KLAPGKEKEPLESQ

    , corresponding to amino acids 24-37 of Human PIM1 (NP_002639.1).

  • ポジティブ・コントロール
    • Human Spleen

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 2.5 - 5 µg/ml.

ターゲット情報

  • 機能May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis.
  • 組織特異性Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated on both serine/threonine and tyrosine residues.
  • 細胞内局在Cytoplasm. Nucleus and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Oncogene PIM 1 antibody
    • Oncogene PIM1 antibody
    • PIM 1 antibody
    • pim 1 kinase 44 kDa isoform antibody
    • Pim 1 kinase antibody
    • pim 1 oncogene (proviral integration site 1) antibody
    • Pim 1 oncogene antibody
    • PIM antibody
    • PIM1 antibody
    • pim1 kinase 44 kDa isoform antibody
    • PIM1_HUMAN antibody
    • Pim2 antibody
    • PIM3 antibody
    • Proto oncogene serine/threonine protein kinase Pim 1 antibody
    • Proto-oncogene serine/threonine-protein kinase Pim-1 antibody
    • Proviral integration site 1 antibody
    • Proviral integration site 2 antibody
    see all

Anti-PIM1 antibody 画像

  • ab118497 at 2.5 µg/ml staining PIM1 in Human Spleen by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-PIM1 antibody (ab118497) 使用論文

ab118497 has not yet been referenced specifically in any publications.

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