製品の概要

  • 製品名Pifithrin-α-HBr
  • 製品の詳細
    p53 Inhibitor
  • 生理活性の詳細p53 Inhibitor. Specifically blocks tumor supressor p53 transcriptional activity and can supress heat shock and glucocorticoid signalling pathways. Additionally offers protection to cells from p53 mediated apoptosis. Active in vivo; protects mice from chemotherapy side effects associated with p53 induction. Also aryl hydrocarbon receptor (AHR) agonist.
  • 精製度> 98%
  • 特記事項

    Pifithrin-?-HBr is light senstive and it is recommended that the compound is protected from light.

製品の特性

    Pifithrin-α-HBr (ab120478) 使用論文

    This product has been referenced in:
    • Sohn D  et al. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ 16:869-78 (2009). Read more (PubMed: 19229248) »
    • Hoagland MS  et al. The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. J Pharmacol Exp Ther 314:603-10 (2005). Read more (PubMed: 15843497) »
    • Komarova EA  et al. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 278:15465-8 (2003). Read more (PubMed: 12637507) »
    • Komarov PG  et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285:1733-7 (1999). Read more (PubMed: 10481009) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"