製品の概要

製品の詳細

  • 由来
    Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab4964 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PICK 1, catalog ab3420. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • dJ1039K5
    • MGC15204
    • OTTHUMP00000028509
    • PICK 1
    • Pick1
    • PICK1_HUMAN
    • PRKCA binding protein
    • PRKCA-binding protein
    • PRKCABP
    • Protein interacting with C kinase 1
    • Protein interacting with PRKCA
    • Protein interacting with PRKCA 1
    • Protein kinase C alpha binding protein
    • Protein kinase C-alpha-binding protein
    • Protein that interacts with C kinase 1
    see all
  • 機能
    Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
  • 組織特異性
    Ubiquitous.
  • 配列類似性
    Contains 1 AH domain.
    Contains 1 PDZ (DHR) domain.
  • 翻訳後修飾
    Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
  • 細胞内局在
    Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
  • Information by UniProt

参考文献

ab4964 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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