製品の概要

  • 製品名Anti-PI3K p85 (phospho Y607) antibody
    PI3K p85 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PI3K p85 (phospho Y607)
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human PI3K p85 (phospho Y607) conjugated to Keyhole Limpet Haemocyanin (KLH). Peptide sequence around phosphorylation site of Tyrosine 607 (D-Q-Y(p)-S-L) derived from Human PI3K p85.
    Database link: P27986

  • ポジティブ・コントロール
    • Rat liver extract.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab182651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 84 kDa.

ターゲット情報

  • 機能Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
  • 組織特異性Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
  • 配列類似性Belongs to the PI3K p85 subunit family.
    Contains 1 Rho-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • ドメインThe SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
  • 翻訳後修飾Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
    Phosphorylated. Dephosphorylated by PTPRJ.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GRB 1 antibody
    • GRB1 antibody
    • p85 alpha antibody
    • p85 antibody
    • P85A_HUMAN antibody
    • Phosphatidylinositol 3 kinase associated p 85 alpha antibody
    • Phosphatidylinositol 3 kinase regulatory 1 antibody
    • Phosphatidylinositol 3 kinase regulatory subunit alpha antibody
    • Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha) antibody
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody
    • Phosphatidylinositol 3-kinase regulatory subunit alpha antibody
    • Phosphoinositide 3 kinase regulatory subunit 1 (alpha) antibody
    • Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha) antibody
    • Phosphoinositide 3 kinase regulatory subunit 1 antibody
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha) antibody
    • PI3 kinase p85 subunit alpha antibody
    • PI3-kinase regulatory subunit alpha antibody
    • PI3-kinase subunit p85-alpha antibody
    • PI3K antibody
    • PI3K regulatory subunit alpha antibody
    • Pik3r1 antibody
    • PtdIns 3 kinase p85 alpha antibody
    • PtdIns-3-kinase regulatory subunit alpha antibody
    • PtdIns-3-kinase regulatory subunit p85-alpha antibody
    see all

Anti-PI3K p85 (phospho Y607) antibody 画像

  • All lanes : Anti-PI3K p85 (phospho Y607) antibody (ab182651) at 1/500 dilution

    Lane 1 : Rat liver extract
    Lane 2 : Rat liver extract with antigen-specific peptide


    Predicted band size : 84 kDa

Anti-PI3K p85 (phospho Y607) antibody (ab182651) 使用論文

This product has been referenced in:
  • Tu M  et al. MicroRNA-127-5p regulates osteopontin expression and osteopontin-mediated proliferation of human chondrocytes. Sci Rep 6:25032 (2016). WB ; Human . Read more (PubMed: 27126955) »
  • Kang EB & Cho JY Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice. J Exerc Nutrition Biochem 19:199-209 (2015). WB ; Mouse . Read more (PubMed: 26527331) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"