Anti-PI 3 Kinase p85 alpha (phospho Y607) 抗体 (ab182651)

製品の概要

  • 製品名
    Anti-PI 3 Kinase p85 alpha (phospho Y607) antibody
    PI 3 Kinase p85 alpha 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PI 3 Kinase p85 alpha (phospho Y607)
  • 特異性
    ab182651 detects endogenous level of PI 3 Kinase p85 only when phosphorylated at Tyrosine 607.
  • アプリケーション
    適用あり: WB, IHCmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human PI 3 Kinase p85 alpha (phospho Y607) conjugated to keyhole limpet haemocyanin. Peptide sequence around phosphorylation site of Tyrosine 607 (D-Q-Y(p)-S-L) derived from Human PI3K p85.
    Database link: P27986

  • ポジティブ・コントロール
    • Rat liver extract.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab182651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 84 kDa.
IHC Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
  • 組織特異性
    Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
  • 配列類似性
    Belongs to the PI3K p85 subunit family.
    Contains 1 Rho-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • ドメイン
    The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
  • 翻訳後修飾
    Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
    Phosphorylated. Dephosphorylated by PTPRJ.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GRB1 antibody
    • p85 alpha antibody
    • p85 antibody
    • P85A_HUMAN antibody
    • Phosphatidylinositol 3 kinase associated p 85 alpha antibody
    • Phosphatidylinositol 3 kinase regulatory 1 antibody
    • Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) antibody
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody
    • Phosphatidylinositol 3-kinase regulatory subunit alpha antibody
    • Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) antibody
    • PI3 kinase p85 subunit alpha antibody
    • PI3-kinase regulatory subunit alpha antibody
    • PI3-kinase subunit p85-alpha antibody
    • PI3K antibody
    • PI3K regulatory subunit alpha antibody
    • Pik3r1 antibody
    • PtdIns 3 kinase p85 alpha antibody
    • PtdIns-3-kinase regulatory subunit alpha antibody
    • PtdIns-3-kinase regulatory subunit p85-alpha antibody
    see all

Anti-PI 3 Kinase p85 alpha (phospho Y607) antibody 画像

  • Immunohistochemistry of human brain tissue labeling PI 3 Kinase p85 (phospho Y607) with ab182651 at 1/200.

  • All lanes : Anti-PI 3 Kinase p85 alpha (phospho Y607) antibody (ab182651) at 1/500 dilution

    Lane 1 : Rat liver extract
    Lane 2 : Rat liver extract with antigen-specific peptide


    Predicted band size : 84 kDa

Anti-PI 3 Kinase p85 alpha (phospho Y607) antibody (ab182651) 使用論文

This product has been referenced in:
  • Huang G  et al. Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway. Int J Mol Med 39:559-568 (2017). Human . Read more (PubMed: 28112381) »
  • Liu Y  et al. Pro-inflammatory cytokine-driven PI3K/Akt/Sp1 signalling and H2S production facilitates the pathogenesis of severe acute pancreatitis. Biosci Rep 37:N/A (2017). Read more (PubMed: 28396512) »

See all 8 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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