The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Detects a band of approximately 102 kDa (predicted molecular weight: 102 kDa).
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis.
Ubiquitously expressed, with a highest expression in skeletal muscle.
Belongs to the PI3/PI4-kinase family. Contains 1 PI3K/PI4K domain.
Wang Y et al. Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation. PLoS One11:e0163896 (2016).
Read more (PubMed: 27711237) »
Lian J et al. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ18:60-71 (2011).
Read more (PubMed: 20577262) »