Anti-PHYH 抗体 (ab118195)
Key features and details
- Rabbit polyclonal to PHYH
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-PHYH antibody -
製品の詳細
Rabbit polyclonal to PHYH -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to amino acids 34-321 of Human PHYH (BC029512).
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ポジティブ・コントロール
- Human fetal kidney and liver lysates; Human breast carcinoma tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Lyophilized:Reconstitute in 200µl sterile water -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab118195の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 39 kDa.
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IHC-P |
1/100 - 1/500.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 39 kDa. |
IHC-P
1/100 - 1/500. |
ターゲット情報
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機能
Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. -
組織特異性
Expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle. -
パスウェイ
Lipid metabolism; fatty acid metabolism. -
関連疾患
Defects in PHYH are a cause of Refsum disease (RD) [MIM:266500]. RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentosa, peripheral neuropathy, cerebellar ataxia, and elevated protein levels in the cerebrospinal fluid (CSF). Patients exhibit accumulation of the branched-chain fatty acid, phytanic acid, in blood and tissues. Less constant features are nerve deafness, anosmia, skeletal abnormalities, ichthyosis, cataracts and cardiac impairment. Manifestations of the disease appear in the second or third decade of life. -
配列類似性
Belongs to the PhyH family. -
細胞内局在
Peroxisome. - Information by UniProt
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参照データベース
- Entrez Gene: 5264 Human
- Entrez Gene: 16922 Mouse
- Entrez Gene: 114209 Rat
- Omim: 602026 Human
- SwissProt: O14832 Human
- SwissProt: O35386 Mouse
- SwissProt: P57093 Rat
- Unigene: 498732 Human
see all -
別名
- LN1 antibody
- LNAP1 antibody
- LNAP1, mouse, homolog of antibody
see all
画像
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All lanes : Anti-PHYH antibody (ab118195) at 1/500 dilution
Lane 1 : Human fetal kidney lysate
Lane 2 : Human fetal liver lysate
Predicted band size: 39 kDa -
ab118195, at 1/100 dilution, staining PHYH in formalin-fixed, paraffin-embedded Human breast carcinoma tissue showing cytoplasmic staining, by Immunohistochemistry.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab118195 は論文での使用が確認できていません。