製品の概要

  • 製品名Anti-Phospholamban (phospho S16 + T17) antibody
    Phospholamban 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Phospholamban (phospho S16 + T17)
  • 特異性Detects endogenous levels of Phospholamban only when phosphorylated at serine 16 and threonine 17
  • アプリケーション適用あり: WB, ICC/IF, ELISAmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from human Phospholamban around the phosphorylation site of serine 16 and threonine 17 (R-A-SP-TP-I-E).

  • ポジティブ・コントロール
    • HuvEc cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab62170 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 6 kDa. PubMed: 24386101
ICC/IF 1/500 - 1/1000.
ELISA 1/5000.

ターゲット情報

  • 機能Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
  • 組織特異性Heart muscle (at protein level).
  • 関連疾患Cardiomyopathy, dilated 1P
    Cardiomyopathy, familial hypertrophic 18
  • 配列類似性Belongs to the phospholamban family.
  • 翻訳後修飾Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
  • 細胞内局在Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Mitochondrion membrane. Membrane. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cardiac phospholamban antibody
    • CMD1P antibody
    • CMH18 antibody
    • PLB antibody
    • Pln antibody
    • PPLA_HUMAN antibody
    see all

Anti-Phospholamban (phospho S16 + T17) antibody 画像

  • Immunofluorescence analysis of HuvEc cells, using Phospholamban (phospho S16 + T17) antibody (ab62170) at 1/500 - 1/1000 dilution, in the presence (right panel) and absence (left panel) of immunising phosphopeptide.

Anti-Phospholamban (phospho S16 + T17) antibody (ab62170) 使用論文

This product has been referenced in:
  • Huang Y  et al. Sarcoplasmic phospholamban protein is involved in the mechanisms of postresuscitation myocardial dysfunction and the cardioprotective effect of nitrite during resuscitation. PLoS One 8:e82552 (2013). WB ; Rat . Read more (PubMed: 24386101) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab62170.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"