Anti-Phospholamban (phospho S16) 抗体 [EPR1911] (ab92697)

製品の概要

  • 製品名Anti-Phospholamban (phospho S16) antibody [EPR1911]
    Phospholamban 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR1911] to Phospholamban (phospho S16)
  • アプリケーション適用あり: WB, IPmore details
    適用なし: IHC-P
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    A phospho specific peptide corresponding to residues surrounding Serine 16 of Human Phospholamban.

  • ポジティブ・コントロール
    • Fetal heart lysate
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab92697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IP
  • 追加情報IP: 1/50.
    WB: 1/200,000 - 1/500,000. Detects a band of approximately 11 kDa (predicted molecular weight: 6 kDa).

    Is unsuitable for IHC-P.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
    • 組織特異性Heart muscle (at protein level).
    • 関連疾患Cardiomyopathy, dilated 1P
      Cardiomyopathy, familial hypertrophic 18
    • 配列類似性Belongs to the phospholamban family.
    • 翻訳後修飾Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
    • 細胞内局在Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Mitochondrion membrane. Membrane. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cardiac phospholamban antibody
      • CMD1P antibody
      • CMH18 antibody
      • PLB antibody
      • Pln antibody
      • PPLA_HUMAN antibody
      see all

    Anti-Phospholamban (phospho S16) antibody [EPR1911] 画像

    • All lanes : Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697) at 1/200000 dilution

      Lane 1 : Fetal heart lysate (untreated)
      Lane 2 : Fetal heart lysate (treated with LP)

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution

      Predicted band size : 6 kDa

    Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697) 使用論文

    ab92697 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab92697.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"