Anti-Phospholamban 抗体 (ab86930)

製品の概要

  • 製品名Anti-Phospholamban antibody
    Phospholamban 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Phospholamban
  • 特異性No cross reactivity with other proteins is observed.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human Phospholamban aa 2-16 (N terminal).
    Sequence:

    EKVQYLTRSAIRRAS


    Database link: P26678

  • ポジティブ・コントロール
    • Rat heart tissue lysate.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 6 kDa.

ターゲット情報

  • 機能Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
  • 組織特異性Heart muscle (at protein level).
  • 関連疾患Cardiomyopathy, dilated 1P
    Cardiomyopathy, familial hypertrophic 18
  • 配列類似性Belongs to the phospholamban family.
  • 翻訳後修飾Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
  • 細胞内局在Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Mitochondrion membrane. Membrane. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cardiac phospholamban antibody
    • CMD1P antibody
    • CMH18 antibody
    • PLB antibody
    • Pln antibody
    • PPLA_HUMAN antibody
    see all

Anti-Phospholamban antibody 画像

  • All lanes : Anti-Phospholamban antibody (ab86930) at 1 µg/ml

    Lane 1 : Rat heart tissue lysate
    Lane 2 : Rat heart tissue lysate


    Predicted band size : 6 kDa
    Observed band size : 11 kDa (why is the actual band size different from the predicted?)

Anti-Phospholamban antibody (ab86930) 使用論文

ab86930 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. We have not tested these antibodies in guinea pig and therefore cannot guarantee they will work, however there is high homology between the immunogen and the guinea pig sequence for all three. Normally we predictlikely reac...

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Thank you for contacting Abcam.

I would be very happy to help answer your questions:

1 - What is the difference between ab86930 and ab85146? Which is more suitable for guinea pig?

- Both antibodies target different areas of t...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"