製品の概要

  • 製品名Anti-Phospholamban antibody
    Phospholamban 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Phospholamban
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH from the S16 region of Human Phospholamban.

  • ポジティブ・コントロール
    • Jurkat cell line lysate and Mouse heart tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab103237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 6 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
  • 組織特異性Heart muscle (at protein level).
  • 関連疾患Cardiomyopathy, dilated 1P
    Cardiomyopathy, familial hypertrophic 18
  • 配列類似性Belongs to the phospholamban family.
  • 翻訳後修飾Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
  • 細胞内局在Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Mitochondrion membrane. Membrane. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cardiac phospholamban antibody
    • CMD1P antibody
    • CMH18 antibody
    • PLB antibody
    • Pln antibody
    • PPLA_HUMAN antibody
    see all

Anti-Phospholamban antibody 画像

  • Anti-Phospholamban antibody (ab103237) at 1/100 dilution + Jurkat cell line lysate at 35 µg

    Predicted band size : 6 kDa
  • ab103237, at 1/50 dilution, staining Phospholamban in formalin-fixed, paraffin-embedded Mouse heart tissue tissue by Immunohistochemistry followed by peroxidase conjugation of the secondary antibody and DAB detection.

Anti-Phospholamban antibody (ab103237) 使用論文

ab103237 has not yet been referenced specifically in any publications.

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