PHCCC, allosteric potentiator at mGlu4 (ab120043)
Key features and details
- Selective allosteric potentiator at mGlu4. Also group I antagonist.
- CAS Number: 179068-02-1
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
PHCCC, allosteric potentiator at mGlu4 -
製品の詳細
Selective allosteric potentiator at mGlu4. Also group I antagonist. -
生理活性の詳細
Selective allosteric potentiator of mGlu4. Anti-Parkinson and anxiolytic effects in vivo. Also antagonist at Group I metabotropic receptors.
-
CAS 番号
179068-02-1 -
構造式
製品の特性
-
体系名
(E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide
-
分子量
294.31 -
分子式
C17H14N2O3 -
PubChem 登録番号
5866327 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM
-
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
ON=C1c4ccccc4OC2(CC12)C(=O)Nc3ccccc3 -
由来
Synthetic
-
研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120043 は 3 報の論文で使用されています。
- Yin S et al. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34:79-94 (2014). PubMed: 24381270
- Gosnell HB et al. mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology 36:1599-607 (2011). PubMed: 21451497
- Goudet C et al. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain 137:112-24 (2008). PubMed: 17900808