The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Stable for one year.
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Acidic (leucine rich) nuclear phosphoprotein 32 family member B
Acidic leucine rich nuclear phosphoprotein 32 family member B
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Acidic nuclear phosphoprotein 32 family member B
Acidic protein rich in leucines
Proliferation related acidic leucine rich protein
Putative HLA-DR-associated protein I-2
Silver stainable protein SSP 29
Silver stainable protein SSP29
Silver-stainable protein SSP29
機能Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
組織特異性Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
配列類似性Belongs to the ANP32 family. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.
ドメインHistone binding is mediated by the concave surface of the LRR region.
翻訳後修飾Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
細胞内局在Nucleus. Accumulates in the nuclei at the S phase and Cytoplasm. Lacks a nuclear localization signal.