Anti-PGP9.5 抗体 (ab72910)
Key features and details
- Chicken polyclonal to PGP9.5
- Suitable for: WB, ICC/IF
- Reacts with: Rat
- Isotype: IgY
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-PGP9.5 antibody
PGP9.5 一次抗体 製品一覧 -
製品の詳細
Chicken polyclonal to PGP9.5 -
由来種
Chicken -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Rat -
免疫原
Recombinant full length human PGP9.5 purified from E. coli.
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ポジティブ・コントロール
- Rat hippocampal homogenate and Rat mixed neuron/glial cultures.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.065% Sodium azide -
Concentration information loading...
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精製度
IgY fraction -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgY -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab72910の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/2500. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).
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ICC/IF | (1) |
1/500.
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特記事項 |
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WB
1/2500. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa). |
ICC/IF
1/500. |
ターゲット情報
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機能
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. -
組織特異性
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. -
関連疾患
Parkinson disease 5
Neurodegeneration with optic atrophy, childhood-onset -
配列類似性
Belongs to the peptidase C12 family. -
翻訳後修飾
O-glycosylated. -
細胞内局在
Cytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain. - Information by UniProt
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参照データベース
- Entrez Gene: 29545 Rat
- SwissProt: Q00981 Rat
- Unigene: 107213 Rat
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別名
- Epididymis luminal protein 117 antibody
- Epididymis secretory protein Li 53 antibody
- HEL 117 antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (7)
ab72910 は 7 報の論文で使用されています。
- Yu W et al. Role of P2X4Receptor in Mouse Voiding Function. Sci Rep 8:1838 (2018). ICC/IF . PubMed: 29382907
- Chen QQ et al. Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease. Transl Neurodegener 7:13 (2018). PubMed: 29988485
- Wong R et al. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Brain Behav Immun N/A:N/A (2018). PubMed: 30453020
- McQuade RM et al. Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons. Front Physiol 8:391 (2017). IHC-P ; Mouse . PubMed: 28642718
- Guan NN et al. Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2. Br J Pharmacol 172:4024-37 (2015). PubMed: 25917171
- Fu YY et al. 3-D imaging and illustration of mouse intestinal neurovascular complex. Am J Physiol Gastrointest Liver Physiol 304:G1-11 (2013). ICC/IF ; Mouse . PubMed: 23086917
- Allen C et al. Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J Immunol 189:381-92 (2012). PubMed: 22661091