製品の概要

  • 製品名
    PF 670462
  • 製品の詳細
    Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor
  • 生理活性の詳細
    Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo.

    Also available in simple stock solutions (ab146728) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Sprouse J  et al. Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms. Psychopharmacology (Berl) 210:569-76 (2010). Read more (PubMed: 20407760) »
  • Meng QJ  et al. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc Natl Acad Sci U S A 107:15240-5 (2010). Read more (PubMed: 20696890) »
  • Badura L  et al. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. J Pharmacol Exp Ther 322:730-8 (2007). Read more (PubMed: 17502429) »

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