製品の概要

  • 製品名Anti-PEX5 antibody
    PEX5 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PEX5
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 180-229 (ATDRWYDEYH PEEDLQHTAS DFVAKVDDPK LANSEFLKFV RQIGEGQVSL) of Human PEX5 (NP_000310).

  • ポジティブ・コントロール
    • ACHN cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab94532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 71 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
  • 組織特異性Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 関連疾患Defects in PEX5 are a cause of adrenoleukodystrophy neonatal (NALD) [MIM:202370]. NALD is a peroxisome biogenesis disorder (PBD) characterized by the accumulation of very long-chain fatty acids, adrenal insufficiency and mental retardation. Inheritance is autosomal recessive.
    Defects in PEX5 are a cause of Zellweger syndrome (ZWS) [MIM:214100]. ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life.
    Defects in PEX5 may be a cause of infantile Refsum disease (IRD) [MIM:266510]. IRD is a mild peroxisome biogenesis disorder (PBD). Clinical features include early onset, mental retardation, minor facial dysmorphism, retinopathy, sensorineural hearing deficit, hepatomegaly, osteoporosis, failure to thrive, and hypocholesterolemia. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid.
  • 配列類似性Belongs to the peroxisomal targeting signal receptor family.
    Contains 7 TPR repeats.
  • 細胞内局在Cytoplasm. Peroxisome membrane. Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ50634 antibody
    • FLJ50721 antibody
    • FLJ51948 antibody
    • PBD2A antibody
    • PBD2B antibody
    • Peroxin 5 antibody
    • Peroxin-5 antibody
    • Peroxisomal biogenesis factor 5 antibody
    • Peroxisomal C terminal targeting signal import receptor antibody
    • Peroxisomal C-terminal targeting signal import receptor antibody
    • Peroxisomal targeting signal 1 (SKL type) receptor antibody
    • Peroxisomal targeting signal 1 receptor antibody
    • Peroxisomal targeting signal import receptor antibody
    • Peroxisomal targeting signal receptor 1 antibody
    • Peroxisome receptor 1 antibody
    • pex5 antibody
    • PEX5_HUMAN antibody
    • PTS1 BP antibody
    • PTS1 receptor antibody
    • PTS1-BP antibody
    • PTS1R antibody
    • PXR1 antibody
    see all

Anti-PEX5 antibody 画像

  • Anti-PEX5 antibody (ab94532) at 1 µg/ml (in 5% skim milk / PBS buffer) + ACHN cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 71 kDa

Anti-PEX5 antibody (ab94532) 使用論文

ab94532 has not yet been referenced specifically in any publications.

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