製品の概要

  • 製品名Anti-PEX19 antibody
    PEX19 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PEX19
  • アプリケーション適用あり: WB, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1 - 269 of Human PEX19 (NP_002848).

  • ポジティブ・コントロール
    • WB: MOLT4 whole cell lysate; ICC/IF: A549 cell IHC-P: SW480 xenograft

法規制情報

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified by antigen affinity chromatography.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab95959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 33 kDa.
IHC-P 1/100 - 1/500.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
  • 組織特異性Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.
  • 関連疾患Defects in PEX19 are the cause of peroxisome biogenesis disorder complementation group 14 (PBD-CG14) [MIM:600279]; also known as PBD-CGJ. PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies.
    Defects in PEX19 are a cause of Zellweger syndrome (ZWS) [MIM:214100]. ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life.
  • 配列類似性Belongs to the peroxin-19 family.
  • 細胞内局在Cytoplasm. Peroxisome membrane. Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 33 kDa housekeeping protein antibody
    • D1S2223E antibody
    • HK33 antibody
    • Housekeeping gene 33kD antibody
    • OK/SW-cl.22 antibody
    • PBD12A antibody
    • Peroxin 19 antibody
    • Peroxin-19 antibody
    • Peroxisomal biogenesis factor 19 antibody
    • Peroxisomal farnesylated protein antibody
    • PEX19 antibody
    • PEX19_HUMAN antibody
    • PMP1 antibody
    • PMPI antibody
    • PXF antibody
    • PXMP1 antibody
    see all

Anti-PEX19 antibody 画像

  • Anti-PEX19 antibody (ab95959) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 33 kDa
  • ab95959, at a 1/200 dilution, staining PEX19 in paraformaldehyde fixed A549 cell by Immunofluorescence analysis.
    Image on the right: merged with DNA probe.
  • ab95959, at a 1/500 dilution, staining PEX19 in paraffin embedded SW480 xenograft by Immunohistochemistry.

Anti-PEX19 antibody (ab95959) 使用論文

ab95959 has not yet been referenced specifically in any publications.

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Thank you for your email.

I have checked the sequence homology between human and T brucei. proteins. Unfortunately, the sequences does not show any kind of homology at all so it will be difficult to predict the corss-reactivity of PEX19 antib...

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As discussed please send the T. Brucei sequence details to us by replying this email.

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