製品の概要

  • 製品名Anti-PER2 antibody
    PER2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to PER2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    C-DQQPKAPLTRDE

    with a Cysteine residue linker, corresponding to amino acids 1029-1040 of Human PER2 (NP_073728.1).

  • ポジティブ・コントロール
    • Human heart and placenta tissues.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

ターゲット情報

  • 機能Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
    NPAS2-BMAL1
    BMAL2-induced transactivation.
  • 組織特異性Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low level in lung.
  • 関連疾患Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • 配列類似性Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • 翻訳後修飾Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation.
  • 細胞内局在Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Circadian clock protein PERIOD 2 antibody
    • FASPS antibody
    • FASPS1 antibody
    • hPER 2 antibody
    • hPER2 antibody
    • KIAA0347 antibody
    • OTTHUMP00000164476 antibody
    • PER 2 antibody
    • PER2 antibody
    • PER2_HUMAN antibody
    • Period 2 antibody
    • Period 2 isoform 1 antibody
    • Period circadian clock 2 antibody
    • Period circadian protein 2 antibody
    • Period circadian protein homolog 2 antibody
    • Period homolog 2 (Drosophila) antibody
    • Period homolog 2 antibody
    • Period, Drosophila, homolog of, 2 antibody
    • Period2 antibody
    see all

Anti-PER2 antibody 画像

  • ab118489 at 7.5µg/ml staining PER2 in Formalin-fixed, Paraffin-embedded Human heart tissue by Immunohistochemistry.
  • ab118489 at 7.5µg/ml staining PER2 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry.

Anti-PER2 antibody (ab118489) 使用論文

ab118489 has not yet been referenced specifically in any publications.

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