製品の概要

  • 製品名Anti-PER1 antibody
    PER1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PER1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Rabbit, Cow, Dog, Pig, Chinese Hamster
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1100 - 1200 of Mouse PER1.

  • ポジティブ・コントロール
    • This antibody gave a positive signal in Mouse Testis tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 136 kDa).

ターゲット情報

  • 機能Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
    NPAS2-BMAL1
    BMAL2-induced transactivation.
  • 組織特異性Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. Low level in kidney.
  • 配列類似性Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • 翻訳後修飾Phosphorylated on serine residues by CSNK1E. Also can be phosphorylated by the delta isoform. Phosphorylation by CSNK1 retains PER1 in the cytoplasm and leads to its ubiquitination and subsequent degradation. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated.
  • 細胞内局在Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Circadian clock protein PERIOD 1 antibody
    • Circadian clock protein PERIOD1 antibody
    • Circadian pacemaker protein Rigui antibody
    • hPER 1 antibody
    • hPER antibody
    • hPER1 antibody
    • KIAA0482 antibody
    • MGC88021 antibody
    • PER 1 antibody
    • PER antibody
    • PER1 antibody
    • PER1 protein antibody
    • PER1_HUMAN antibody
    • Period 1 antibody
    • Period circadian protein homolog 1 antibody
    • Period drosophila homolog of antibody
    • Period homolog 1 antibody
    • Period1 antibody
    • RIGUI antibody
    see all

Anti-PER1 antibody 画像

  • Anti-PER1 antibody (ab99253) at 1 µg/ml + Testis (Mouse) Tissue Lysate at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 136 kDa
    Observed band size : 120 kDa (why is the actual band size different from the predicted?)


    Exposure time : 20 minutes

Anti-PER1 antibody (ab99253) 使用論文

ab99253 has not yet been referenced specifically in any publications.

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