製品の概要

  • 製品名Anti-PELP1 antibody
    PELP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PELP1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region within the amino acids 1000-1050 of Human MNAR (accession number: AAN41255.1)

  • ポジティブ・コントロール
    • Human breast adenocarcinoma. Mouse ovary tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.
    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K.
    • 組織特異性Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed.
    • ドメインThe Glu-rich region mediates histones interaction.
      The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus. Cytoplasm. Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors.
    • Information by UniProt
    • 参照データベース
    • 別名
      • glutamic acid- and leucine-rich protein 1 antibody
      • HMX3 antibody
      • MNAR antibody
      • Modulator of non-genomic activity of estrogen receptor antibody
      • Modulator of nongenomic activity of estrogen receptor antibody
      • P160 antibody
      • Pelp1 antibody
      • PELP1 proline glutamic acid leucine rich protein 1 antibody
      • PELP1_HUMAN antibody
      • proline and glutamic acid rich nuclear protein antibody
      • Proline glutamate and leucine rich protein 1 antibody
      • Proline- antibody
      • proline-, glutamic acid- and leucine-rich protein 1 antibody
      • Transcription factor HMX3 antibody
      see all

    Anti-PELP1 antibody 画像

    • Detection of Human MNAR by Immunohistochemistry.
      Sample: FFPE section of Human breast adenocarcinoma.
      Antibody: ab84094 used at a dilution of 1/500.
    • Detection of Mouse MNAR by Immunohistochemistry.
      Sample: FFPE section of Mouse ovary.
      Antibody:ab84094 used at a dilution of 1/100.
      Detection: DAB.

    Anti-PELP1 antibody (ab84094) 使用論文

    This product has been referenced in:
    • Janssen SF  et al. Gene expression and functional annotation of the human ciliary body epithelia. PLoS One 7:e44973 (2012). IHC-FoFr ; Human . Read more (PubMed: 23028713) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"