製品の概要

  • 製品名Anti-PELP1 antibody
    PELP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PELP1
  • アプリケーション適用あり: IHC-P, IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between residue 25 and 75 of human MNAR (AAN41255.1).

  • ポジティブ・コントロール
    • HeLa whole cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab70798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/500 - 1/2000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IP Use at 2-5 µg/mg of lysate.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K.
    • 組織特異性Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed.
    • ドメインThe Glu-rich region mediates histones interaction.
      The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus. Cytoplasm. Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors.
    • Information by UniProt
    • 参照データベース
    • 別名
      • glutamic acid- and leucine-rich protein 1 antibody
      • HMX3 antibody
      • MNAR antibody
      • Modulator of non-genomic activity of estrogen receptor antibody
      • Modulator of nongenomic activity of estrogen receptor antibody
      • P160 antibody
      • Pelp1 antibody
      • PELP1 proline glutamic acid leucine rich protein 1 antibody
      • PELP1_HUMAN antibody
      • proline and glutamic acid rich nuclear protein antibody
      • Proline glutamate and leucine rich protein 1 antibody
      • Proline- antibody
      • proline-, glutamic acid- and leucine-rich protein 1 antibody
      • Transcription factor HMX3 antibody
      see all

    Anti-PELP1 antibody 画像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testicular seminoma tissue labelling PELP1 with ab70798 at 1/1000 (1µg/ml). Detection: DAB.

    Anti-PELP1 antibody (ab70798) 使用論文

    ab70798 has not yet been referenced specifically in any publications.

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