製品の概要

  • 製品名Anti-PEG10 antibody
    PEG10 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to PEG10
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein (Human), PEG10 (NP_001035242.1, 325 a.a)

  • ポジティブ・コントロール
    • Human stomach tissue lysate, PEG10 transfected 293T cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab68780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: 1/500 - 1/1000. Detects bands of approximately 42 and 100 kDa (predicted molecular weight for isoform RF1: 37 kDa. predicted molecular weight for isoform RF1/RF2:80 kDa ).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.
    • 組織特異性Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the HepG2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).
    • 配列類似性Contains 1 CCHC-type zinc finger.
    • 発生段階Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation.
    • 翻訳後修飾Isoform RF1/RF2 undergoes proteolytic cleavage.
    • 細胞内局在Nucleus. Cytoplasm. Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the HepG2 cell line. Colocalized with ALK1.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AA407948 antibody
      • Edr antibody
      • Embryonal carcinoma differentiation regulated antibody
      • Embryonal carcinoma differentiation-regulated protein antibody
      • HB 1 antibody
      • HB1 antibody
      • KIAA1051 antibody
      • Mammalian retrotransposon-derived protein 2 antibody
      • Mar2 antibody
      • Mart2 antibody
      • MEF3 like 1 antibody
      • MEF3-like protein 1 antibody
      • MEF3L antibody
      • MEF3L1 antibody
      • MyEF 3 antibody
      • Myelin expression factor 3-like protein 1 antibody
      • Paternally expressed 10 antibody
      • Paternally expressed gene 10 ORF1 antibody
      • Paternally expressed gene 10 protein antibody
      • Peg10 antibody
      • PEG10 protein antibody
      • PEG10_HUMAN antibody
      • Putative uncharacterized protein PEG10 antibody
      • Retrotransposon gag domain containing 3 antibody
      • Retrotransposon gag domain-containing protein 3 antibody
      • Retrotransposon-derived gag-like polyprotein antibody
      • Retrotransposon-derived protein PEG10 antibody
      • RGAG3 antibody
      • Ty3/Gypsy-like protein antibody
      see all

    Anti-PEG10 antibody 画像

    • Anti-PEG10 antibody (ab68780) at 1/500 dilution + Human stomach tissue lysate at 50 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 37 kDa
      Observed band size : 100 kDa (why is the actual band size different from the predicted?)
    • All lanes : Anti-PEG10 antibody (ab68780) at 1/500 dilution

      Lane 1 : PEG10 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 37 kDa
      Observed band size : 42 kDa (why is the actual band size different from the predicted?)

    Anti-PEG10 antibody (ab68780) 使用論文

    ab68780 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab68780.
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