製品の概要

  • 製品名Anti-PEAR1 antibody
  • 製品の詳細
    Rabbit polyclonal to PEAR1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: PSDPNTCSFW ESFTTTTKES HSRPFSLLPS EPCERPWEGP HTCPQPTVVY RTVYRQVVKT DHRQRLQCCH GFYES, corresponding to amino acids 23-97 of Human.

  • ポジティブ・コントロール
    • Human bone marrow tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab122261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
  • 組織特異性Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.
  • 配列類似性Belongs to the MEGF family.
    Contains 9 EGF-like domains.
    Contains 1 EMI domain.
  • 翻訳後修飾Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.
  • 細胞内局在Cell membrane. Detected on the cell surface in resting platelets.
  • Information by UniProt
  • 参照データベース
  • 別名
    • hPEAR1 antibody
    • JEDI antibody
    • MEGF12 antibody
    • Multiple EGF-like domains protein 12 antibody
    • Multiple epidermal growth factor-like domains protein 12 antibody
    • Pear1 antibody
    • PEAR1_HUMAN antibody
    • Platelet endothelial aggregation receptor 1 antibody
    • RP11-107D16.3 antibody
    see all

Anti-PEAR1 antibody 画像

  • ab122261, at 1/35, staining PEAR1 in paraffin embedded Human bone marrow tissue by Immunohistochemistry.

Anti-PEAR1 antibody (ab122261) 使用論文

ab122261 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"