製品の概要

  • 製品名Anti-PDZK1 antibody
    PDZK1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PDZK1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 195-224 of Human PDZK1 (NP_002605.2).

  • ポジティブ・コントロール
    • NCI-H292 cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123798 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 57 kDa.

ターゲット情報

  • 機能A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
  • 組織特異性Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
  • 配列類似性Belongs to the NHER family.
    Contains 4 PDZ (DHR) domains.
  • ドメインThe PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.
    Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains.
    The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1.
    The PDZ 1 domain interacts with BCR.
  • 細胞内局在Cytoplasm. Membrane. Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.
  • Information by UniProt
  • 参照データベース
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    • Na/Pi cotransporter C-terminal-associated protein 1 antibody
    • Na/Pi cotransporter C-terminal-associated protein antibody
    • NaPi Cap1 antibody
    • NaPi-Cap1 antibody
    • NaPiCap1 antibody
    • NHERF 3 antibody
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    • NHERF3 antibody
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    see all

Anti-PDZK1 antibody 画像

  • Anti-PDZK1 antibody (ab123798) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

    Predicted band size : 57 kDa

Anti-PDZK1 antibody (ab123798) 使用論文

ab123798 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123798.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"