The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報WB: 1/500 - 1/1000. Detects a band of approximately 54 kDa (predicted molecular weight: 61 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
組織特異性Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
配列類似性Contains 4 PDZ (DHR) domains.
細胞内局在Cell membrane. Cytoplasm. Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells.