製品の概要

  • 製品名Anti-PDGFC antibody
    PDGFC 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PDGFC
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, selected from the N-terminal region of Human PDGFC.

  • ポジティブ・コントロール
    • MDA-MB231 cell line lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab112915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 39 kDa.

ターゲット情報

  • 機能Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.
  • 組織特異性Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.
  • 配列類似性Belongs to the PDGF/VEGF growth factor family.
    Contains 1 CUB domain.
  • 発生段階In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the undifferentiated mesenchyme (at protein level).
  • 翻訳後修飾Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.
    Sumoylated by SUMO1.
    N-glycosylated.
  • 細胞内局在Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Fallotein antibody
    • hSCDGF antibody
    • PDGF-C antibody
    • PDGFC antibody
    • PDGFC latent form antibody
    • PDGFC receptor-binding form antibody
    • PDGFC_HUMAN antibody
    • Platelet derived growth factor C antibody
    • Platelet-derived growth factor C, receptor-binding form antibody
    • SCDGF antibody
    • Secretory growth factor like protein antibody
    • Secretory growth factor like protein fallotein antibody
    • Spinal cord derived growth factor antibody
    • Spinal cord-derived growth factor antibody
    • VEGF E antibody
    • VEGF-E antibody
    see all

Anti-PDGFC antibody 画像

  • Anti-PDGFC antibody (ab112915) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size : 39 kDa

Anti-PDGFC antibody (ab112915) 使用論文

ab112915 has not yet been referenced specifically in any publications.

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