製品の概要

  • 製品名
    Anti-PDGFAA + PDGFBB antibody
  • 製品の詳細
    Goat polyclonal to PDGFAA + PDGFBB
  • 特異性
    The antibody reacts with PKBa. It may recognize the PKBß isoform. The sequence is identical in mouse, rat, and bovine PKBa, highly conserved in PKBß, and diverges in the PKB? isoform.
  • アプリケーション
    適用あり: WB, Neutralising, Indirect ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Natural human PDGF

  • ポジティブ・コントロール
    • PDGF-responsive NR6R-3T3 fibroblasts.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab50201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
Neutralising
Indirect ELISA
  • 追加情報
    I-ELISA: Use at a concentration of 0.25 µg/ml.
    Neut: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
    • 組織特異性
      Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
    • 関連疾患
      Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF.
    • 配列類似性
      Belongs to the PDGF/VEGF growth factor family.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 製品の状態
      PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Secreted.
    • 別名
      • becaplermin antibody
      • c-sis antibody
      • FLJ12858 antibody
      • PDGF 1 antibody
      • PDGF 2 antibody
      • PDGF B antibody
      • PDGF B chain antibody
      • PDGF subunit B antibody
      • PDGF-2 antibody
      • Pdgfb antibody
      • PDGFB_HUMAN antibody
      • Platelet derived growth factor beta polypeptide antibody
      • platelet-derived growth factor 2 antibody
      • Platelet-derived growth factor B chain antibody
      • Platelet-derived growth factor beta polypeptide antibody
      • Platelet-derived growth factor subunit B antibody
      • Platelet-derived growth factor, beta polypeptide (oncogene SIS) antibody
      • Proto-oncogene c-Sis antibody
      • SIS antibody
      • SSV antibody
      see all

    プロトコール

    参考文献

    This product has been referenced in:
    • Baghy K  et al. Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. FEBS J 280:2150-64 (2013). Read more (PubMed: 23448253) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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