Anti-PDGF Receptor alpha 抗体 [APA5] (ab90967)

製品の概要

  • 製品名Anti-PDGF Receptor alpha antibody [APA5]
    PDGF Receptor alpha 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [APA5] to PDGF Receptor alpha
  • アプリケーション適用あり: WB, IHC-Fr, Flow Cytmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Fusion protein corresponding to Mouse PDGF Receptor alpha (extracellular). Fusion protein containing the extracellular domain of Mouse PDGF Receptor alpha and the Fc portion of Human IgG1 purified from the culture supernatant of transfected COS1 cells

  • ポジティブ・コントロール
    • NIH3T3 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-Fr
Flow Cyt
  • 追加情報Flow Cyt: Use 1µg for 106 cells in a 100 µl total staining volume.
    IHC-Fr: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 123 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    • 組織特異性Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
    • 関連疾患Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Alpha-type platelet-derived growth factor receptor antibody
      • CD140 antigen-like family member A antibody
      • CD140a antibody
      • CD140a antigen antibody
      • MGC74795 antibody
      • PDGF alpha chain antibody
      • PDGF-R-alpha antibody
      • PDGFR 2 antibody
      • PDGFR alpha antibody
      • PDGFR2 antibody
      • PDGFRA antibody
      • PDGFRA/BCR fusion antibody
      • PGFRA_HUMAN antibody
      • Platelet derived growth factor receptor 2 antibody
      • Platelet derived growth factor receptor alpha antibody
      • Platelet derived growth factor receptor alpha polypeptide antibody
      • Platelet derived growth factor receptor antibody
      • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody
      • RHEPDGFRA antibody
      see all

    Anti-PDGF Receptor alpha antibody [APA5] 画像

    • Staining of NIH/3T3 cells with 0.5 µg Rat IgG2a control antibody (open histogram) or 0.5 µg of ab90967 (colored histogram) followed by Biotin Anti-Rat IgG secondary antibody. Total viable cells were analysed.

    Anti-PDGF Receptor alpha antibody [APA5] (ab90967) 使用論文

    This product has been referenced in:
    • Rondahl V  et al. Lrig2-deficient mice are protected against PDGFB-induced glioma. PLoS One 8:e73635 (2013). Read more (PubMed: 24023893) »
    • Miyawaki T  et al. Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina. J Neurosci 24:8124-34 (2004). Read more (PubMed: 15371513) »

    See all 3 Publications for this product

    Product Wall

    Thank you for contacting Abcam regarding ab90967.


    We have not tested this antibody directly in-house for cross reactivity against CD140b.The clone is APA5 and according to the development paper for this clone, this antibody is specific ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"