Anti-PDGFR alpha 抗体 (ab124392)
Key features and details
- Rabbit polyclonal to PDGFR alpha
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-PDGFR alpha antibody
PDGFR alpha 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PDGFR alpha -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Cow, Dog, Pig, Xenopus laevis -
免疫原
Synthetic peptide corresponding to Human PDGFR alpha aa 1035-1053 conjugated to keyhole limpet haemocyanin.
Sequence:cGKRNRHSSQTSEESAIETG
Database link: P16234 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at +4°C. Do Not Freeze. -
バッファー
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 99% Tris glycine, 0.88% Sodium chloride -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab124392の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (2) |
1/100.
|
特記事項 |
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IHC-P
1/100. |
ターゲット情報
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機能
Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity. -
組織特異性
Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue. -
関連疾患
Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 395509 Chicken
- Entrez Gene: 442860 Dog
- Entrez Gene: 5156 Human
- Entrez Gene: 100627123 Pig
- Entrez Gene: 25267 Rat
- Omim: 173490 Human
- SwissProt: P16234 Human
- SwissProt: P20786 Rat
see all -
別名
- Alpha-type platelet-derived growth factor receptor antibody
- CD140 antigen-like family member A antibody
- CD140a antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab124392 は 9 報の論文で使用されています。
- Li C et al. An Integrative Metabolomic and Network Pharmacology Study Revealing the Regulating Properties of Xihuang Pill That Improves Anlotinib Effects in Lung Cancer. Front Oncol 11:697247 (2021). PubMed: 34434895
- Achkar A et al. Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice. Oxid Med Cell Longev 2020:8282157 (2020). PubMed: 32566103
- Lis GJ et al. Identification of CD34+/PGDFRa+ Valve Interstitial Cells (VICs) in Human Aortic Valves: Association of Their Abundance, Morphology and Spatial Organization with Early Calcific Remodeling. Int J Mol Sci 21:N/A (2020). PubMed: 32878299
- Buffolo M et al. Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Cell Rep 29:270-282.e5 (2019). PubMed: 31597091
- Qian C et al. Conditional deletion of platelet derived growth factor receptor alpha (Pdgfra) in urorectal mesenchyme causes mesenchyme apoptosis and urorectal developmental anomalies in mice. Cell Death Differ 26:1396-1410 (2019). PubMed: 30323271
- Stammnitz MR et al. The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. Cancer Cell 33:607-619.e15 (2018). IHC-P . PubMed: 29634948
- Steger CM et al. Gene therapy with antisense oligonucleotides silencing c-myc reduces neointima formation and vessel wall thickness in a mouse model of vein graft disease. Exp Mol Pathol 105:1-9 (2018). IHC-P ; Mouse . PubMed: 29775572
- Duan M et al. Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGF-mediated JAK-STAT signaling pathway. Mol Med Rep 18:1651-1659 (2018). PubMed: 29845251
- Chen YJ et al. Schwann cells induce Proliferation and Migration of Oligodendrocyte Precursor Cells Through Secretion of PDGF-AA and FGF-2. J Mol Neurosci 56:999-1008 (2015). PubMed: 26044662