Anti-PDGF Receptor alpha 抗体 [16A1] (Biotin) (ab99924)

製品の概要

• 製品名
  Anti-PDGF Receptor alpha antibody [16A1] (Biotin)
  PDGF Receptor alpha 一次抗体 製品一覧
• 製品の詳細
  Mouse monoclonal [16A1] to PDGF Receptor alpha (Biotin)
• 標識
  Biotin
• 特異性
  recognizes CD140a / PDGF receptor alpha, the 170 kDa alpha chain of platelet derived growth factor receptor, which is widely expressed on a variety of mesenchymal derived cells and plays pro proliferative or anti proliferative roles in various tumours.
• アプリケーション
  適用あり: ICC, Flow Cytmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Tissue/ cell preparation - CD140a-transfected NIH 3T3 cells

• 特記事項

  The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファー
  Preservative: 15mM Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• 精製度
  Size exclusion
• 特記事項（精製）
  Purified by immunoaffinity chromatography (> 95% by SDS-PAGE) prior to conjugation.
• ポリ/モノ
  モノクローナル
• クローン名
  16A1
• アイソタイプ
  IgG1
• 研究分野
  • Cardiovascular
  • Angiogenesis
  • Growth Factors
  • Other

  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Kinases
  • Receptor Tyrosine Kinases

  • Signal Transduction
  • Growth Factors/Hormones
  • PDGF

  • Cancer
  • Growth factors
  • PDGF

  • Cancer
  • Oncoproteins/suppressors
  • Oncoproteins
  • Growth factor receptors

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Inflammatory mediators

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

アプリケーション

ターゲット情報

• 機能
  Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
• 組織特異性
  Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
• 関連疾患
  Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
• 配列類似性
  Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
  Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
  Contains 1 protein kinase domain.
• 細胞内局在
  Membrane.

• Target information above from: UniProt accession P16234 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 5156 Human
  • Omim: 173490 Human
  • SwissProt: P16234 Human
  • Unigene: 74615 Human
• 別名
  • Alpha-type platelet-derived growth factor receptor antibody
  • CD140 antigen-like family member A antibody
  • CD140a antibody

  • CD140a antigen antibody
  • MGC74795 antibody
  • PDGF alpha chain antibody
  • PDGF-R-alpha antibody
  • PDGFR 2 antibody
  • PDGFR alpha antibody
  • PDGFR2 antibody
  • PDGFRA antibody
  • PDGFRA/BCR fusion antibody
  • PGFRA_HUMAN antibody
  • Platelet derived growth factor receptor 2 antibody
  • Platelet derived growth factor receptor alpha antibody
  • Platelet derived growth factor receptor alpha polypeptide antibody
  • Platelet derived growth factor receptor antibody
  • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody
  • RHEPDGFRA antibody

  see all

プロトコール

• Flow cytometry protocols
• Immunocytochemistry & immunofluorescence protocols