Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
Detection of PDE8A by Western Blot of Immunprecipitate.
Lane 1: ab109597 at 1µg/ml staining PDE8A in HeLa whole cell lysate immunoprecipitated using ab109597 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Lane 2: Control IgG
Detection: Chemiluminescence with exposure time of 30 seconds.
All lanes : Anti-PDE8A antibody (ab109597) at 1 µg
Lane 1 : IP of 6 µg of PDE8A antibody/mg HeLa cell lysate Lane 2 : Control IgG with HeLa cell lysate