製品の概要
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製品名PDE6 beta peptide
PDE6 beta タンパク質・ペプチド 製品一覧
製品の詳細
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由来Synthetic
関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab5890 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Blocking
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精製度> 95 % SDS-PAGE.
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製品の状態Liquid
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備考
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PDE6 beta, catalog ab5663. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (70-fold) for competitive inhibition of antibody-protein binding reactions.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
関連情報
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別名
- 5''-cyclic phosphodiesterase subunit beta
- Congenital stationary night blindness 3 autosomal dominant
- CSNB 3
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機能This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
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関連疾患Defects in PDE6B are the cause of retinitis pigmentosa type 40 (RP40) [MIM:613801]. RP40 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Defects in PDE6B are a cause of congenital stationary night blindness autosomal dominant type 2 (CSNBAD2) [MIM:163500]; also known as congenital stationary night blindness Rambusch type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. -
配列類似性Belongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains. -
細胞内局在Membrane.
- Information by UniProt
参考文献
ab5890 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"