製品の概要

  • 製品名Anti-PDE4D7 antibody
  • 製品の詳細
    Rabbit polyclonal to PDE4D7
  • 特異性The antibody does not cross reacts with PDE4D1, D2, D3, D4 and D5 variants. It also does not cross react with PDE4A, PDE4B or PDE4C.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide from unique region near N terminal of the PDE4D7 variant. (Rat)

  • ポジティブ・コントロール
    • Rat cortical membranes.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: BSA
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab14629 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/200. Detects a band of approximately 110 kDa.

ターゲット情報

  • 関連性Cyclic AMP dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4, D6, D7, and D8; 1, 2). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios, and their activity is regulated in tandem with GPCRs stimulation and selective phosphorylation by PKA and other kinases. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins. Anti PDE4D antibodies are ideal tools for studying regulation, expression, phosphorylation, and protein protein interactions of PDE4D variants employing pull down immunoprecipitation protocol.
  • 参照データベース
  • 別名
    • DPDE3 antibody
    • HSPDE4D antibody
    • PDE43 antibody
    • PDE4D antibody
    • Phosphodiesterase 4D antibody
    • Phosphodiesterase 4D cAMP-specific antibody
    see all

Anti-PDE4D7 antibody 画像

  • Lane 1 : Anti-PDE4D7 antibody (ab14629)
    Lanes 2 - 3 : Anti-PDE4D7 antibody (ab14629) at 1/750 dilution

    Lane 1 : Negative Control
    Lane 2 : Human Rec-PDE4D7 (1 ng)
    Lane 3 : Human Rec-PDE4D7 (10 ng)

Anti-PDE4D7 antibody (ab14629) 使用論文

ab14629 has not yet been referenced specifically in any publications.

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