製品の概要

  • 製品名Anti-PDE4D5 antibody
  • 製品の詳細
    Rabbit polyclonal to PDE4D5
  • 特異性This antibody does not cross-react with other members of the PDE4D family or with other PDE4 proteins (PDE4A, B and C) or with other PDE family members.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A 20 amino acid synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (N terminal).

  • ポジティブ・コントロール
    • Rat cortical membranes.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.02% Sodium Azide
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab14626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/200 - 1/250. Detects a band of approximately 105 kDa.

ターゲット情報

  • 関連性Cyclic AMP-dependent Phosphodiesterase 4 type D (PDE4D) family includes 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation and selective phosphorylation by PKA and other kinases. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short-term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanisms involved protein-protein interactions with cytoskeletal scaffolding proteins.
  • 参照データベース
  • 別名
    • DPDE3 antibody
    • hPDE4D5 antibody
    • PDE4D antibody
    • PDE4DN2 antibody
    • Phosphodiesterase 4D antibody
    • Phosphodiesterase 4D cAMP-specific antibody
    • STRK1 antibody
    see all

Anti-PDE4D5 antibody (ab14626) 使用論文

ab14626 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"