製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to PDE4D3
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide:

    HVNNFPFRRHS-C

    , corresponding to N terminal amino acids 3-12 of Human PDE4D3 (variant AAA97892.1).

  • ポジティブ・コントロール
    • Rat Brain lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 77 kDa.

ターゲット情報

  • 関連性
    Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short-term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein-protein interactions with cytoskeletal scaffolding proteins.
  • 細胞内局在
    Cell Membrane and Cytoplasmic
  • 参照データベース
  • 別名
    • DPDE3 antibody
    • hPDE4D3 antibody
    • HSPDE4D antibody
    • PDE43 antibody
    • PDE4D antibody
    • PDE4DN2 antibody
    • Phosphodiesterase 4D antibody
    • Phosphodiesterase 4D cAMP-specific antibody
    • STRK1 antibody
    see all

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プロトコール

参考文献

ab59021 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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