製品の概要

  • 製品名Anti-PDE4D antibody
    PDE4D 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to PDE4D
  • アプリケーション適用あり: WB, IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    QPEACVIDDRSPDT

    , corresponding to C terminal amino acids 796-809 of Human PDE4D.

  • ポジティブ・コントロール
    • Human Heart and Human Skeletal Muscle tissue; COS cell lysates transfected with Human PDE4D1 and transfected with Human PDE4D3

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab112018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 1 µg/ml. Predicted molecular weight: 91 kDa.
IHC-P Use a concentration of 5 µg/ml.
ELISA 1/128000.

ターゲット情報

  • 機能Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
  • 組織特異性Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
  • パスウェイPurine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
  • 関連疾患Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.
  • 配列類似性Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
  • 翻訳後修飾Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.
  • 細胞内局在Cytoplasm. Membrane. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • cAMP specific 3',5' cyclic phosphodiesterase 4D antibody
    • DKFZp686M11213 antibody
    • 5''-cyclic phosphodiesterase 4D antibody
    • cAMP specific phosphodiesterase 4D antibody
    • cAMP specific phosphodiesterase PDE4D6 antibody
    • cAMP-specific 3'' antibody
    • DPDE3 antibody
    • Dunce like phosphodiesterase E3 antibody
    • FLJ97311 antibody
    • HSPDE4D antibody
    • PDE43 antibody
    • Pde4d antibody
    • PDE4D_HUMAN antibody
    • PDE4DN2 antibody
    • Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody
    • Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila) antibody
    • Phosphodiesterase 4D cAMP specific antibody
    • Phosphodiesterase 4D, cAMP specific (dunce) antibody
    • STRK1 antibody
    see all

Anti-PDE4D antibody 画像

  • Immunohistochemical analysis of PDE4D expression in formalin-fixed, paraffin-embedded Human heart tissue using ab112018 at 5 µg/ml.
  • Immunohistochemical analysis of PDE4D expression in formalin-fixed, paraffin-embedded Human skeletal muscle tissue using ab112018 at 5 µg/ml.
  • All lanes : Anti-PDE4D antibody (ab112018) at 1 µg/ml

    Lane 1 : COS cell lysates transfected with Human PDE4D1
    Lane 2 : COS cell lysates transfected with Human PDE4D3
    Lane 3 : COS cell lysates untransfected

    Lysates/proteins at 25 µg per lane.

    Developed using the ECL technique

    Predicted band size : 91 kDa

Anti-PDE4D antibody (ab112018) 使用論文

ab112018 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. I apologise for the delay, I wanted to check this case with my lab colleagues.
Regarding ab59249, the amino acid range of this immunogen is aaXXXX of human PDE4D with accession# Q08499 (http://www.uniprot.org/uniprot/Q...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"