製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PDE1A
  • アプリケーション
    適用あり: IP, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptides (conserved sequence near the N-terminal) unique to PDE1A family members.

  • ポジティブ・コントロール
    • Rat testis.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab14599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP 1/200.
WB 1/250 - 1/500. Predicted molecular weight: 61 kDa. This antibody labels multiple bands in 65-72 kDa range all believed to be various PDE1A variants expressed in various rat tissues.
IHC-P Use at an assay dependent concentration. PubMed: 19924104

ターゲット情報

  • 機能
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
  • 組織特異性
    Several tissues, including brain, kidney, testes and heart.
  • 配列類似性
    Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3' 5' cyclic nucleotide phosphodiesterase antibody
    • 5''-cyclic nucleotide phosphodiesterase 1A antibody
    • 61 kDa Cam PDE antibody
    • 61 kDa Cam-PDE antibody
    • Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody
    • Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase antibody
    • Calcium/calmodulin-dependent 3'' antibody
    • Calmodulin-dependent Phosphodiesterase antibody
    • Cam PDE 1A antibody
    • Cam-PDE 1A antibody
    • CAM-PDE-1A antibody
    • HCAM 1 antibody
    • hCam-1 antibody
    • HCAM1 antibody
    • HSPDE1A antibody
    • MGC26303 antibody
    • PDE 1A antibody
    • PDE1A antibody
    • PDE1A_HUMAN antibody
    • Phosphodiesterase 1A antibody
    • Phosphodiesterase 1A calmodulin dependent antibody
    see all

参考文献

This product has been referenced in:
  • Kogiso H  et al. A low [Ca(2+)]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia. Pflugers Arch N/A:N/A (2017). Mouse . Read more (PubMed: 28477148) »
  • Giachini FR  et al. Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Hypertension 57:655-63 (2011). WB ; Rat . Read more (PubMed: 21282562) »

See all 4 Publications for this product

レビューと Q&A

Thank you for contacting Abcam.

The peptide for ab14599 has now added been added to the catalogue as PDE1A peptide (ab140070). Also the immnuogen for ab14599 was from human PDE1A N-terminal epitope form *******.
If there is anything else I...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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