製品の概要

  • 製品名Anti-PDE11A antibody
    PDE11A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PDE11A
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide corresponding to Human PDE11A (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • ポジティブ・コントロール
    • Human Testis tissue.
  • 特記事項For short term storage: -4°C

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.7
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab61822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  • 組織特異性Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
  • 関連疾患Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2) [MIM:610475]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome.
  • 配列類似性Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • ドメインThe tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading to stimulate the enzyme activity.
  • 細胞内局在Cytoplasm > cytosol.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody
    • cAMP and cGMP phosphodiesterase 11A antibody
    • cGMP phosphodiesterase 11A antibody
    • Cyclic nucleotide phosphodiesterase 11A antibody
    • Dual 3'' antibody
    • Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody
    • pde11 antibody
    • PDE11_HUMAN antibody
    • pde11a antibody
    • PDE11A1 antibody
    • pde11a2 antibody
    • Phosphodiesterase 11A antibody
    • PPNAD2 antibody
    see all

Anti-PDE11A antibody 画像

  • ab61822, at 5µg/ml, staining human PDE11A in testis by immunohistochemistry. Formalin-fixed paraffin-embedded tissue.

Anti-PDE11A antibody (ab61822) 使用論文

ab61822 has not yet been referenced specifically in any publications.

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