製品の概要
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製品名Anti-PDCD6 antibody, prediluted
PDCD6 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to PDCD6, prediluted
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由来種Rabbit
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アプリケーション適用あり: IHC-Pmore details
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種交差性交差種: Human
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免疫原
Synthetic peptide corresponding to the C-terminal of human PDCD6.
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ポジティブ･コントロール
- Human lung carcinoma.
製品の特性
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製品の状態Prediluted
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保存方法Shipped at 4°C. Store at +4°C.
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バッファーPreservative: 0.1% Sodium Azide
Constituents: 1% BSA, 50mM Tris, pH 7.6 -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab64104 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
追加情報
IHC-P: Ready-to-use for 30 min at room temperature. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.
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配列類似性Contains 5 EF-hand domains.
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細胞内局在Nucleus membrane. Endoplasmic reticulum membrane. Nucleus. Endosome. Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
- Information by UniProt
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参照データベース
- Entrez Gene: 10016 Human
- Omim: 601057 Human
- SwissProt: O75340 Human
- Unigene: 50823 Human
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別名
- AIP1 antibody
- ALG 2 antibody
- ALG-2-interacting protein 1 antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDCD6 antibody, prediluted (ab64104)Immunohistochemical analysis of PDCD6 expression in human lung carcinoma using ab64104 on formalin-fixed, paraffin-embedded tissue. Staining pattern: Cytoplasmic and cell membrane.
参考文献
ab64104 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"