製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PCSK9
  • アプリケーション
    適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Chimpanzee, Macaque monkey, Gorilla, Common marmoset
  • 免疫原

    Synthetic peptide corresponding to Mouse PCSK9 aa 152-163.
    Sequence:

    VFAQSIPWNLER


    Database link: Q80W65

  • ポジティブ・コントロール
    • HepG2 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab95478 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF 1/50.
WB Use at an assay dependent dilution. Predicted molecular weight: 74 kDa.

ターゲット情報

  • 機能
    May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
  • 組織特異性
    Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
  • 関連疾患
    Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
  • 配列類似性
    Belongs to the peptidase S8 family.
    Contains 1 peptidase S8 domain.
  • 翻訳後修飾
    The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Convertase subtilisin/kexin type 9 preproprotein antibody
    • FH3 antibody
    • HCHOLA3 antibody
    • Hypercholesterolemia autosomal dominant 3 antibody
    • LDLCQ1 antibody
    • NARC 1 antibody
    • NARC-1 antibody
    • NARC1 antibody
    • Neural apoptosis regulated convertase 1 antibody
    • Neural apoptosis-regulated convertase 1 antibody
    • PC 9 antibody
    • PC9 antibody
    • PCSK 9 antibody
    • PCSK9 antibody
    • PCSK9_HUMAN antibody
    • Proprotein convertase 9 antibody
    • Proprotein convertase PC9 antibody
    • Proprotein convertase subtilisin/kexin type 9 antibody
    • PSEC0052 antibody
    • Subtilisin/kexin like protease PC9 antibody
    • Subtilisin/kexin-like protease PC9 antibody
    see all

画像

  • ab95478 staining PCSK9 in HepG2 cells by immunofluorescence. The positive staining cytoplasm was visualized in red with a Cy3 conjugated goat anti-rabbit secondary antibody.

参考文献

ab95478 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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