製品の概要

  • 製品名Anti-PCB antibody
    PCB 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to PCB
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Horse, Cow, Dog, Human, Pig, Rhesus monkey
  • 免疫原

    Synthetic peptide:

    C-KFKEVKKAYVEANQ

    , corresponding to internal sequence amino acids 886-899 of Human PCB (NP_000911.2; NP_001035806.1; NP_071504.2).

  • ポジティブ・コントロール
    • Mouse Liver lysate.
  • 特記事項All reported variants (NP_000911.2; NP_001035806.1; NP_071504.2) represent identical protein.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報Peptide ELISA: Antibody detection limit dilution 1/16000.
    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 150 kDa (predicted molecular weight: 130 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
    • パスウェイCarbohydrate biosynthesis; gluconeogenesis.
    • 関連疾患Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.
    • 配列類似性Contains 1 ATP-grasp domain.
      Contains 1 biotin carboxylation domain.
      Contains 1 biotinyl-binding domain.
      Contains 1 carboxyltransferase domain.
    • 細胞内局在Mitochondrion matrix.
    • Information by UniProt
    • 参照データベース
    • 別名
      • mitochondrial antibody
      • OTTHUMP00000235155 antibody
      • OTTHUMP00000235156 antibody
      • PC antibody
      • PCB antibody
      • Pcx antibody
      • PYC_HUMAN antibody
      • Pyruvate carboxylase antibody
      • Pyruvate carboxylase mitochondrial antibody
      • Pyruvic carboxylase antibody
      see all

    Anti-PCB antibody 画像

    Anti-PCB antibody (ab77376) 使用論文

    This product has been referenced in:
    • Jornayvaz FR  et al. Thyroid hormone receptor-a gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology 153:583-91 (2012). WB ; Mouse . Read more (PubMed: 22147010) »
    • Jornayvaz FR  et al. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. Am J Physiol Endocrinol Metab 299:E808-15 (2010). WB ; Mouse . Read more (PubMed: 20807839) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"