製品の概要
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製品名Anti-PC4 antibody
PC4 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to PC4
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由来種Rabbit
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アプリケーション適用あり: IHC-Pmore details
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種交差性交差種: Mouse, Human
交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Rhesus monkey, Gorilla, Orangutan, Platypus
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免疫原
Synthetic peptide corresponding to a region between residues 77 and 127 of Human PC4 (NP_006704.2)
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ポジティブ･コントロール
- Human: bladder carcinoma, breast carcinoma, colon carcinoma, linitis plastica stomach cancer, ovarian carcinoma, pancreatic islet cell tumor, prostate carcinoma, skin basal cell carcinoma, skin melanoma, skin squamous cell carcinoma, small cell lung cancer, stomach adenocarcinoma, testicular seminoma. Mouse: skin, seratoma
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab84459 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
追加情報
IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may improve staining.
Note: likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Note: likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
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配列類似性Belongs to the transcriptional coactivator PC4 family.
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翻訳後修飾Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
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細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 10923 Human
- Entrez Gene: 20024 Mouse
- Entrez Gene: 192269 Rat
- Omim: 600503 Human
- SwissProt: P53999 Human
- SwissProt: P11031 Mouse
- SwissProt: Q63396 Rat
- Unigene: 229641 Human
see all -
別名
- Activated RNA polymerase II transcriptional coactivator p15 antibody
- Interferon related developmental regulator 1 antibody
- MGC102747 antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PC4 antibody (ab84459)Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast carcinoma tissue using 1/250 ab84459, followed by DAB staining. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PC4 antibody (ab84459)Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue using 1/250 ab84459, followed by DAB staining. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PC4 antibody (ab84459)Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse teratoma tissue using 1/250 ab84459, followed by DAB staining.
参考文献
This product has been referenced in:
- Westphal N et al. Nuclear fragments of the neural cell adhesion molecule NCAM with or without polysialic acid differentially regulate gene expression. Sci Rep 7:13631 (2017). Read more (PubMed: 29051583) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"