製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PC4
  • 特異性
    ab28433 recognises PC4
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein (Human): PC4

  • ポジティブ・コントロール
    • HeLa nuclear extract

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab28433 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000 - 1/5000. Predicted molecular weight: 14 kDa.

ターゲット情報

  • 機能
    General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
  • 配列類似性
    Belongs to the transcriptional coactivator PC4 family.
  • 翻訳後修飾
    Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Activated RNA polymerase II transcriptional coactivator p15 antibody
    • Interferon related developmental regulator 1 antibody
    • MGC102747 antibody
    • p14 antibody
    • P15 antibody
    • PC4 antibody
    • PC4 LSB antibody
    • Positive cofactor 4 antibody
    • RPO2TC1 antibody
    • Sub1 antibody
    • SUB1 homolog antibody
    • TCP4_HUMAN antibody
    see all

プロトコール

参考文献

ab28433 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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