製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to PBX1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Monkey, Zebrafish
  • 免疫原

    Synthetic peptide (

    C-ATNVSAHGSQANSPS

    ) corresponding to internal sequence amino acids 313-327 of Human PBX1 (NP_002576.1).

  • ポジティブ・コントロール
    • Lysates of cell line K562

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab104247 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 47 kDa.

ターゲット情報

  • 機能
    Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation.
  • 組織特異性
    Expressed in all tissues except in cells of the B and T lineage.
  • 関連疾患
    Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family.
  • 配列類似性
    Belongs to the TALE/PBX homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp686B09108 antibody
    • Homeo box protein PBX1 antibody
    • Homeo box protein PRL antibody
    • Homeobox protein PBX 1 antibody
    • Homeobox protein PBX1 antibody
    • Homeobox protein PRL antibody
    • MGC126627 antibody
    • PBX 1 antibody
    • Pbx1 antibody
    • PBX1_HUMAN antibody
    • Pre B cell leukemia homeobox 1 antibody
    • Pre B cell leukemia transcription factor 1 antibody
    • Pre-B-cell leukemia transcription factor 1 antibody
    • PRL antibody
    see all

画像

プロトコール

参考文献

ab104247 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab104247.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録