製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PARP9
  • アプリケーション
    適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from the C terminal region of the short isoform of human PARP9.

  • ポジティブ・コントロール
    • Human Farage non-Hodgkins B-cell lymphoma Human BC-1 B-lymphocyte lymphoma lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 96 kDa).
IP Use at an assay dependent dilution. Use at a concentration of 7 µg/reaction.

ターゲット情報

  • 機能
    Involved in inducing the expression of IFN-gamma-responsive genes.
  • 組織特異性
    Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells.
  • 関連疾患
    Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.
  • 配列類似性
    Contains 2 Macro domains.
    Contains 1 PARP catalytic domain.
  • 細胞内局在
    Cytoplasm > cytosol. Nucleus. Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADP-ribosyltransferase diphtheria toxin-like 9 antibody
    • ARTD9 antibody
    • AW214463 antibody
    • B aggressive lymphoma protein antibody
    • Bagl antibody
    • BAL antibody
    • BAL1 antibody
    • BC003281 antibody
    • DKFZp666B0810 antibody
    • DKFZp686M15238 antibody
    • EC 2.4.2.30 antibody
    • FLJ26637 antibody
    • FLJ35310 antibody
    • FLJ41418 antibody
    • FLJ43593 antibody
    • MGC:7868 antibody
    • MGC156739 antibody
    • MGC7868 antibody
    • OTTMUSP00000028034 antibody
    • PARP 9 antibody
    • PARP-9 antibody
    • Parp9 antibody
    • PARP9_HUMAN antibody
    • Poly (ADP ribose) polymerase family member 9 antibody
    • Poly [ADP-ribose] polymerase 9 antibody
    • RGD1307534 antibody
    see all

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参考文献

This product has been referenced in:
  • Iwata H  et al. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun 7:12849 (2016). Read more (PubMed: 27796300) »
  • Yan Q  et al. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Mol Cell Biol 33:845-57 (2013). Read more (PubMed: 23230272) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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