製品の概要

  • 製品名Anti-PARP3 antibody
    PARP3 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to PARP3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    PARP3 (AAH14260, 1 a.a. ~ 533 a.a) human protein.

  • ポジティブ・コントロール
    • PARP3 transfected 293T lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab70140 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).

ターゲット情報

  • 機能Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
  • 組織特異性Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
  • 配列類似性Contains 1 PARP alpha-helical domain.
    Contains 1 PARP catalytic domain.
  • ドメインAccording to PubMed:10329013, the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.
  • 翻訳後修飾Auto-poly(ADP)-ribosylation.
  • 細胞内局在Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > centrosome > centriole. Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADP ribosyltransferase (NAD+; poly (ADP ribose) antibody
    • ADP ribosyltransferase diphtheria toxin like 3 antibody
    • ADPRT-3 antibody
    • ADPRT3 antibody
    • ADPRTL2 antibody
    • ADPRTL3 antibody
    • ARTD3 antibody
    • hPARP 3 antibody
    • hPARP-3 antibody
    • hPARP3 antibody
    • IRT 1 antibody
    • IRT1 antibody
    • NAD(+) ADP ribosyltransferase 3 antibody
    • NAD(+) ADP-ribosyltransferase 3 antibody
    • NAD+ ADP ribosyltransferase 3 antibody
    • pADPRT 3 antibody
    • pADPRT-3 antibody
    • pADPRT3 antibody
    • PARP 3 antibody
    • PARP-3 antibody
    • PARP3 antibody
    • PARP3_HUMAN antibody
    • Poly (ADP ribose) polymerase family, member 3 antibody
    • Poly (ADP ribose) synthetase 3 antibody
    • Poly [ADP-ribose] polymerase 3 antibody
    • Poly[ADP ribose] synthetase 3 antibody
    • Poly[ADP-ribose] synthase 3 antibody
    see all

Anti-PARP3 antibody 画像

  • All lanes : Anti-PARP3 antibody (ab70140) at 1/500 dilution

    Lane 1 : PARP3 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 60 kDa
    Observed band size : 60 kDa

Anti-PARP3 antibody (ab70140) 使用論文

ab70140 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab70140.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"