Anti-PARL 抗体 (ab118554)
Key features and details
- Rabbit polyclonal to PARL
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
-
製品名
Anti-PARL antibody -
製品の詳細
Rabbit polyclonal to PARL -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rat -
免疫原
Synthetic peptide containing 15 amino acids from the N-terminal region of Human PARL (NP_061092.3).
-
ポジティブ・コントロール
- Human pancreas tissue; 3T3 cell lysate.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab118554の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa.
|
|
IHC-P |
Use a concentration of 5 µg/ml.
|
特記事項 |
---|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
ターゲット情報
-
機能
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. -
配列類似性
Belongs to the peptidase S54 family. -
翻訳後修飾
P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated. -
細胞内局在
Mitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism. - Information by UniProt
-
参照データベース
- Entrez Gene: 55486 Human
- Entrez Gene: 381038 Mouse
- Entrez Gene: 287979 Rat
- Omim: 607858 Human
- SwissProt: Q9H300 Human
- SwissProt: Q5XJY4 Mouse
- SwissProt: Q3B8P0 Rat
- Unigene: 478469 Human
see all -
別名
- Mitochondrial intramembrane cleaving protease PARL antibody
- Mitochondrial intramembrane-cleaving protease PARL antibody
- P-beta antibody
see all
画像
プロトコール
データシートおよび資料
-
Datasheet download
参考文献 (0)
ab118554 は論文での使用が確認できていません。